Sevoflurane is the newest inhalation anesthetic. It is notable because of its unique characteristics. Different methods have been reported for its synthesis, the best one being a two- stage method. In the first stage of this method, 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) reacts with AlCl3 and trioxane to produce sevochlorane. In the second stage sevochlorane reacts with KF in PEG-400 solvent and sevoflurane is achieved. In this research, variables such as PEG-400, KF and reaction time have been optimized. Based on the results obtained, sevofluorane was obtained in 90% yield, under optimized reaction conditions. Also, ionic liquids were used as green solvent. It was found out that fluorination reaction of sevochlorane with KF can also be performed in ionic liquids, but, howevere, with lower yields.The maximum yield was achieved by the use of tetramethylammonium fluoride,TMAF, ionic liquid in 20% yield.