Design and Simulation of a Novel Surface Plasmon Based Bio-Nanosensor for Detection of DNA Hybridization

Document Type : -

Authors

1 Photonic department of Sciences faculty of Imam Hossein University

2 ihu

3 Laser- Optics center of Imam Hossein University

4 Laser Optics center of Imam Hossein University

Abstract

This paper proposes a novel plasmonic sensor for biological applications such as single-stranded DNA detection that it is simulated and analyzed using the FDTD method. The sensor detects the adsorption of DNA molecules in the sensing solution (PBS) by changes in the reflectance of the structure. The mechanism of this sensor is based on the variation of refractive index with the absorption of different concentrations of molecules. The proposed structure consists of metal (gold/silver)-indium tin oxide (ITO)-graphene and an assay medium. The results showed that the ITO metal oxide layer plays an important role in the sensor parameters. By optimizing the thicknesses of metals (gold and silver), the metal oxide, and graphene, we obtained the maximum sensitivity of 75 deg/RIU for the gold-graphene-analyte structure and the maximum detection limit of 58.33 for the silver-ITO-analyte structure. The structures proposed in this paper outperform those presented in previous works. Thus, the proposed biosensor is able to open a new window for biomolecule detection.

Keywords

References

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Journal of Advanced Defense Science & Technology
Volume 11, Issue 3 - Serial Number 41
November 2020
Pages 275-278

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History

  • Receive Date: 23 September 2019
  • Revise Date: 02 January 2020
  • Accept Date: 01 February 2020
  • Publish Date: 22 September 2020

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