Study of Structure- Activity Relationship in somePhosphoramidate Compounds

In recent years application of QSAR technique has shown that, there are mathematical relationships between chemical structures and biological activities of compounds. In this method, by changing some specific directions on main molecule composition like, altering electronical shape, shifting in hydrophobicity values of molecule and certain specific changes in general structure of main molecule composition results in creation of a molecule with new chemo-physical properties and biological activities. In this method, by measuring physical and chemical properties of a family of molecules and comparing their biological activities (like: toxicity, drug properties, etc.), a data bank of molecular properties is created. The method of linkage analysis of molecules is used and important physio-chemical properties and their correlation with specific biological properties is stored in this data bank.In this way, the method provides possibilities to design a new molecule with certain biological properties. As a conclusion, it has been shown that there are very close dependency between biological activities of phosphoramidate compounds and their respective hydrophobicity.